Over the course of four weeks, the formulated suspension was closely monitored for the appearance or absence of undesired physical changes. There were no unwanted physical changes in the prepared suspension (Table 6). This shows that the suspension is physically stable and retains its aesthetic attractiveness and that the excipients employed in the formulation were appropriate [10, 19].
Pharmaceutical films must endure different types of mechanical stress encountered during manufacture, packaging, travel, and consumer handling. The physical characteristics of the vaccine loaded ODF are listed in Table III. Briefly, undamaged films with an average width of 30 mm and thickness of 79 μm were placed between two rubber grippers approximately 21 mm apart. Stress was applied at 10 mm/min until rupture. Studies were conducted with four replicates. Mechanical properties of the vaccine loaded ODF are listed in Table IV. The transverse section of the vaccine loaded ODF is shown in Fig. 7 where the white spots are the vaccine microparticles which are uniformly dispersed throughout the matrix of the film.
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